Study on evaluating 5-fluorouracil loading and releasing of Fe-BDC-PEG materials
164 viewsDOI:
https://doi.org/10.54939/1859-1043.j.mst.FEE.2022.230-236Keywords:
Metal - organic-framework; Drug delivery; 5-fluorouracil; Cancer treatment.Abstract
This paper presents the results of 5 fluorouracil carrying-release of iron (III) framework materials with two ligands of 1,4-benzendiccarboxylic acid and polyethylene glycol diacid synthesized by ultrasonic bath method at an average temperature. Materials before and after 5-fluorouracil were characterized; their properties by scanning electron microscopy (SEM) and infrared spectroscopy (FT-IR) techniques showed that the active ingredient was wholly absorbed into the structural framework of the material without changing the shape and size of the material. The evaluation results for the 5 fluorouracil carrying capacity of Fe-BDC-PEG two-ligand Fe-BDC-PEG framework material showed that the drug absorption capacity reached 358.707 mg/g. The slow release characteristics of the material were also evaluated, showing that the effective release of the active ingredient reached 94.42% after 7 days, and the maximum after 10 days reached 97.68%. The Fe-BDC-PEG@5-FU drug carrier material system is studied to orient the application of cancer treatment when minimizing side effects based on the slow release of the system.
References
[1]. Mohadeseh Safaei, Mohammad Mehdi Foroughi, Nasser Ebrahimpoor, Shohreh Jahani, Ali Omidi, Mehrdad Khatami, “A review on metal-organic frameworks: Synthesis and applications”, Trends in Analytical Chemistry, Vol 118, pp. 401-425, (2019).
[2]. Olivia L. RoseCerasela Zoica Dinu, “Analysis and correlations of metal-organic frameworks: applications and toxicity”, Health and Environmental Safety of Nanomaterials (Second Edition), pp. 253-290, (2021). DOI: https://doi.org/10.1016/B978-0-12-820505-1.00012-2
[3]. Danil N. Dybtsev, Konstantin P. Bryliakov, “Asymmetric catalysis using metal-organic frameworks”, Coordination Chemistry Reviews, Vol 437, 213845, (2021). DOI: https://doi.org/10.1016/j.ccr.2021.213845
[4]. Xuanjie Huang, Lei Huang, Samuel Raj Babu Arulmani, Jia Yan, Qian Li, Jinfeng Tang, Kuilin Wan, Hongguo Zhang, Tangfu Xiao, Minhua Shao, “Research progress of metal organic frameworks and their derivatives for adsorption of anions in water: A review”, Environmental Research, Vol 204, 112381, (2022). DOI: https://doi.org/10.1016/j.envres.2021.112381
[5]. Xiaoying Huang, Zhengjun Gong, Yi Lv, “Advances in metal-organic frameworks-based gas sensors for hazardous substances”, Trends in Analytical Chemistry, Vol. 153, 116644, (2022). DOI: https://doi.org/10.1016/j.trac.2022.116644
[6]. Junaid Haider, Anum Shahzadi, Muhammad Usama Akbar, Izan Hafeez, Iram Shahzadi, Ayesha Khalid, Atif Ashfaq, Syed Ossama Ali Ahmad, S. Dilpazir, Muhammad Imran, Muhammad Ikram, Ghafar Ali, Maaz Khan, Qasim Khan, Muhammad Maqbool, “A review of synthesis, fabrication, and emerging biomedical applications of metal-organic frameworks”, Biomaterials Advances, Vol. 140, 213049, (2022). DOI: https://doi.org/10.1016/j.bioadv.2022.213049
[7]. Mohadeseh Safaei, Mohammad Mehdi Foroughi, Nasser Ebrahimpoor, Shohreh Jahani, Ali Omidi, Mehrdad Khatami, “A review on metal-organic frameworks: Synthesis and applications”, Trends in Analytical Chemistry, Vol. 118, pp. 401-425, (2019). DOI: https://doi.org/10.1016/j.trac.2019.06.007
[8]. Mahnaz Ahmadi, Maryam Ebrahimnia, Mohammad-Ali Shahbazi, Rüstem Keçili, Fatemeh Ghorbani-Bidkorbeh, “Microporous metal–organic frameworks: Synthesis and applications”, Journal of Industrial and Engineering Chemistry, (2022). DOI: https://doi.org/10.1016/j.jiec.2022.07.047
[9]. Brendon W.H. Lee, Amitouj S. Sidhu, Ian C. Francis, Minas T. Coroneo, “5-Fluorouracil in primary, impending recurrent and 2 recurrent pterygium: Systematic review of the efficacy 3 and safety of a surgical adjuvant and intralesional 4 antimetabolite”, The Ocular Surface, (2022).
[10]. Michal Hendrych, Kamila Ríhov, Barbora Adamov, Vojtˇech Hradil, Marek Stiborek, Petr Vlˇcek, Mark´eta Hermanova, Jana Vaˇsíˇckova, Petr Beneˇs, Jan Smarda, Viktor Kanický, Jan Preisler, Jarmila Navratilov, “Disulfiram increases the efficacy of 5-fluorouracil in organotypic cultures of colorectal carcinoma”, Vol. 153, 113465, (2022). DOI: https://doi.org/10.1016/j.biopha.2022.113465
[11]. Christian Rafael Quijia, Camila Lima, Caroline Silva, Renata Carolina Alves, Regina Frem, Marlus Chorilli, “Application of MIL-100(Fe) in drug delivery and biomedicine”, Journal of Drug Delivery Science and Technology, Vol. 61, 102217, (2021). DOI: https://doi.org/10.1016/j.jddst.2020.102217
[12]. Weronika Strzempeka, Elżbieta Menaszek, Barbara Gil, “Fe-MIL-100 as drug delivery system for asthma and chronic obstructive pulmonary disease treatment and diagnosis”, Microporous and Mesoporous Materials, Vol. 280, pp. 264-270, (2019). DOI: https://doi.org/10.1016/j.micromeso.2019.02.018
[13]. Brenda Singco, Li-Hao Liu, Ya-Ting Chen, Yung-Han Shih, Hsi-Ya Huang, Chia-Her Lin, “Approaches to drug delivery: Confinement of aspirin in MIL-100(Fe) and aspirin in the de novo synthesis of metal-organic frameworks”, Microporous and Mesoporous Materials, Vol. 223, pp. 254-260, (2016). DOI: https://doi.org/10.1016/j.micromeso.2015.08.017
[14]. Christian Rafael Quijia, Marcela Tavares Luiz, Richard Perosa Fernandes, Rafael Miguel Sabio, Regina Frem, Marlus Chorilli, “In situ synthesis of piperine-loaded MIL-100 (Fe) in microwave for breast cancer treatment”, Journal of Drug Delivery Science and Technology, Vol. 75, 103718, (2022). DOI: https://doi.org/10.1016/j.jddst.2022.103718
[15]. Hoai Phuong Nguyen Thi, Duc Ha Ninh, “Investigation in loading 5-fluorouracil ability of iron-organic frameworks”, Vietnam Journal of Science and Technology, Vol. 56, pp. 219-227, (2018).
